Immunoablative Therapy with Bone Marrow or Peripheral Stem Cell Transplantation for Systemic Lupus Erythematosus

May 31, 2009 | Evidence Reports


Immunoablative therapy is a complex medical procedure that involves destroying or ablating the abnormal cells from the immune system that are responsible for the disease and then reconstituting the immune system with healthy stem cells harvested from the patient’s own bone marrow or peripheral blood (autologous transplant) or from a donor (allogeneic transplant).

Interest in immunoablative therapy for systemic lupus erythematosus (SLE) arose from observations that cases of pre-existing autoimmune disease coincidental with malignancies have sometimes gone into prolonged remission when the malignancy was treated with immunoablation followed by hematopoietic stem cell transplantation (HSCT).

High-dose chemotherapy, whole-body radiation, and...

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