COVID-19 Clinical Guidelines–Vaccine

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British HIV Association guidelines on immunisation for adults with HIV: SARS-CoV-2 (COVID-19) 2021

Date: 2021
Developer: British HIV Association (BHIVA)

Guideline Focus
Use of SARS-CoV-2 immunisation in people with HIV

Patient Population
Adults with HIV

Major Interventions

  • Choice of vaccine, including HIV- and non-HIV-related risk factors, schedule, and booster
  • Guidance on immune response to vaccine, including risk factors and modified vaccine schedules
  • Patient education on side effects, post-vaccination period, and continuing risk reduction
  • Guidance on antibody testing, co-administration of SARS-CoV-2 vaccines with other vaccines, and passive immunisation with antibodies
  • Deference of vaccine due to acute illness, including COVID-19 infection

Guidance on myocarditis and pericarditis after mRNA COVID-19 vaccines. Version 1.1

Date: 2021 Nov 8
Developer: Cardiac Society of Australia and New Zealand (CSANZ)/Australian Government Department of Health/Royal Australian College of General Practitioners (RACGP)/Australian College of Remote and Rural Medicine (ACRRM)/Australasian College for Emergency Medicine (ACEM)

Guideline Focus
Myocarditis and pericarditis after mRNA COVID-19 vaccines

Patient Population
People with and without a history of chronic cardiovascular conditions

Major Interventions

  • Use of mRNA vaccines (i.e., Comirnaty, Spikevax) based on age and risk of contraindications or severe illness from COVID-19
  • Guidance on advice for people with a history of cardiac conditions and those who experience myocarditis/pericarditis
  • Assessment of suspected myocarditis or pericarditis
  • Guidance on management of myocarditis/pericarditis and follow-up

Interim recommendations for an extended primary series with an additional vaccine dose for COVID-19 vaccination in immunocompromised persons: interim guidance

Date: 2021 Oct 26
Developer: World Health Organization (WHO)

Guideline Focus
Interim guidance on an extended primary series of COVID-19 vaccine, with an additional vaccine dose, for immunocompromised persons

Patient Population
Immunocompromised persons (IPCs)

Major Interventions

  • Indications for extending primary COVID-19 vaccine series to include additional dose, including consideration of timing

Coadministration of seasonal inactivated influenza and COVID-19 vaccines: interim guidance

Date: 2021 Oct 21
Developer: World Health Organization (WHO)

Guideline Focus
Coadministration of seasonal inactivated influenza and COVID-19 vaccines

Patient Population
Individuals receiving both COVID-19 and influenza vaccines

Major Interventions

  • Guidance on coadministration vaccination programmes, including injection placements
  • Post-authorization monitoring and research

The Advisory Committee on Immunization Practices' interim recommendations for additional primary and booster doses of COVID-19 vaccines - United States, 2021

Date: 2021 Nov 5
Developer: Centers for Disease Control and Prevention (CDC)

Guideline Focus
Use of additional primary mRNA COVID-19 vaccine dose and COVID-19 vaccine booster dose

Patient Population
Immunocompromised persons aged ≥18 years who completed a COVID-19 vaccine primary series ≥28 days ago (Pfizer-BioNTech, Moderna) AND persons aged ≥18 years who completed a COVID-19 vaccine primary series ≥6 months ago (Pfizer-BioNTech, also includes patients ≥12 years, Moderna) or ≥2 months ago (Janssen)

Major Interventions

  • Use of an additional primary or booster vaccination dose for the prevention of COVID-19

The Advisory Committee on Immunization Practices’ interim recommendation for use of Pfizer-BioNTech COVID-19 vaccine in children aged 5–11 years — United States, November 2021

Date: 2021 Nov 12
Developer: Centers for Disease Control and Prevention (CDC)

Guideline Focus
Use of Pfizer-BioNTech COVID-19 vaccine in children aged 5–11 years

Patient Population
Children aged 5–11 years

Major Interventions

  • Use of Pfizer-BioNTech vaccine for the prevention of COVID-19

For access to additional guidelines, check out and search the entire ECRI Guidelines Trust® (EGT), a repository of objective, evidence-based clinical practice guidelines.

Return to the ECRI COVID-19 Resource Center